First Presbyterian has wide-reaching missions including local and international.

• "Heal Africa" in the Democratic Republic of the Congo
• Mission Adelante in Kansas City
• Community Dinner sponsored by the Board of Deacons
• Salvation Army in Manhattan
• Emergency Shelter in Manhattan
• Food Pantry in coordination with the Flint Hills Breadbasket
• Backpack Program providing school supplies for local children in need
• Christmas Adopt-a-Child Program also for local children in need